Sunday, February 15, 2015

Insomnia, anxiety, Meanie's disease, vertigo, angle glaucoma,

Asthenic and anxious-neurotic states, anxiety, fear, obsessive-compulsive disorder, psychopathy. Stuttering and tics in children with enuresis. Retention of urine on the background of myelodysplasia. Insomnia and nightmares in the elderly. Prevention of anxiety arising prior to surgery and painful diagnostic studies (premedication).
Meanie's disease, vertigo associated with dysfunction of the vestibular analyzer different genesis (including at otogenny maze of vascular and traumatic disorders); prevention of motion sickness when kinetosis.
Primary open -angle glaucoma (in combination therapy).
As adjunctive therapy in the treatment of alcoholism (and for the relief of psycho pathological disorders in somatovegetativnyh withdrawal syndrome).
Treatment predelirioznyh and delirious states in alcoholism (in combination with conventional means of detoxification). 

Take that medicine ONLY during the day.

Phenibutum, tabletsPharmacological action

Nootropic agent is gamma-amino-beta-phenylbutyric acid hydrochloride. Facilitates GABA-mediated neurotransmission in the CNS (direct effect on GABA-receptors) also has anxiolytic, psychostimulant, antiplatelet and antioxidant effects.
Improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral blood flow (increases the volume and the linear velocity of cerebral blood flow, reduces the tone of brain vessels, improves microcirculation, has antiplatelet effect). Helps reduce or disappearance of anxiety, tension, anxiety and fear, normalizes sleep, has some anticonvulsant effect.
No effect on choline and adrenergic receptors.
Lengthens and shortens the latent period of the duration and severity of nystagmus.
Reduces the appearance of fatigue and vazovegetativnye symptoms (including headache , feeling of heaviness in the head, sleep disturbances, irritability, emotional lability), enhances mental performance.
Improves mental performance (attention, memory, speed and accuracy of sensory-motor reactions).
In exchange reception improves physical and mental performance, improves memory, normalizes sleep; improves the condition of patients with motor and speech disorders. Patients asthenia from the first days of therapy improves health;increases the interest and initiative (motivation activities) without sedation and stimulation. In the application after severe head injury increases the number of mitochondria in the perifocal areas and improves during bioenergetic processes in the brain.
When neurogenic lesions of the heart and the stomach normalizes the process of lipid peroxidation. The elderly does not cause congestion and excessive lethargy, relaxing aftereffect often absent. Improves microcirculation in the eye tissues, reduces the inhibitory effect of ethanol on the CNS. Low toxicity.

Pharmacokinetics

Absorption is high well into all tissues of the body and across the BBB (brain tissue penetrates about 0.1% of the administered dose, and in young and elderly people are much more). Evenly distributed in the liver and kidneys. Metabolized in the liver - 80-95%, pharmacologically inactive metabolites. Not accumulates. After 3 hours, the kidneys begin to stand, with the concentration in the brain tissue and does not exhibit reduced in the brain for a further 6 hours. About 5% is excreted unchanged by the kidneys partially - with bile.

Dosage

Inside, regardless of meals. Dose, dosing frequency and duration of treatment depends on the indication, age of the patient tolerability. Adult dose ranges from 20 mg to 750 mg, for children - from 20 mg to 250 mg.

Drug Interactions

Extends and enhances the effects of sleeping pills, narcotic analgesics , antiepileptic, antipsychotic and antiparkinsonian agents.

Pregnancy and lactation

Be wary of during pregnancy, lactation.

Side effects

CNS: increased irritability, agitation, anxiety, dizziness, headache, drowsiness.
From the digestive system: nausea (at the first admission).
Allergic reactions: skin rash , itching.

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